Selena Corey | Resident Evil: Requiem

1. #1Umbrella Corporation

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   The Umbrella Corporation is a multinational conglomerate with subsidiaries active in a variety of industries from the 1980s to the early 2000s. Umbrella had influence in the production and sale of cosmetics, chemicals, pharmaceuticals, industrial machine production, consumer products, health foods, the transportation industry and tourism. Umbrella's large array of subsidiaries was typical for large-scale corporations, though it was purposely built to cover up illegal activities.

2. #2Project W

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   Project W, or the Wesker Plan, was a eugenics project pioneered by Oswell E. Spencer which intended to develop an advanced race of human beings. The project was named after the first director of the project, Dr. Wesker and all successful child candidates are renamed with this surname. This was one of the most significant viral operations centering around the Progenitor virus. This project was also highly classified to the extent that it was not even included among the Umbrella Archives or in the U.M.F.-013 computer core.

3. #3Oswell E. Spencer

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   Dr. Oswell E. Spencer, Earl Spencer is an aristocratic British billionaire, virologist and eugenicist. One of the founders of Umbrella Pharmaceuticals, Lord Spencer is the CEO and President for its entire existence, which saw its expansion as the Umbrella Corporation over the 1980s.

   A cold, ruthless elitist and ambitious individual, Spencer mercilessly eliminated his rivals and gradually increased his power within the company, which he strictly controlled behind a veil of darkness. Spencer has a vision to remake the world and lead it into a new era, seeing the world's current state as self-destructive. He intended to use the research data accumulated from Bio Organic Weapons to carry his vision out and mould a utopia for mankind with himself as its ruler.

4. #4Bio Organic Weapon, B.O.W.

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   Bio Organic Weapons (B.O.W. for short) are genetically-altered organisms created with the intent of either being used as military and paramilitary weapons, or were created to further research into military and paramilitary weapons. This definition is rigid, and so does not include mutants created due to outbreaks, who are termed "Irregular Mutants".

5. #5Progenitor Virus

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   The Progenitor virus is a family of RNA viruses. Progenitor is immensely ancient and is suspected of being hundreds of millions, if not billions of years old. It is considered to have both aided and hindered the evolution of Earth's ecology through the extremities of its resulting mutations.

   While otherwise behaving as a typical Group VI virus in the Baltimore classification, Progenitor is distinct from all other viruses by being able to reverse lysis in cells and revive organisms dead for considerable lengths of time. Whereas other retroviruses, such as Human Immunodeficiency Virus, target particular cells of a particular animal's body, Progenitor is capable of infecting the cells of any organism, whether animal, fungal, plant, or bacterial.

   Considerable research on Progenitor has been undertaken since its discovery in the late 1960s, and a number of engineered strains have since come into existence primarily for bioweapons research.

6. #6U.M.F.-013

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   The U.M.F.-013 was an Umbrella computer core containing the Umbrella Archives and data on their experiments, in which it also contained the A.I. "Red Queen" and her counterpart "White Queen". Sometime later, Sergei reinstalled this computer system at the Caucasus laboratory.

   In 2003, Albert Wesker, after having a battle with a mutated Sergei, downloaded all of the U.M.F.s data and formatted the U.M.F., wiping out the entire data on the computer itself.

7. #7S.T.A.R.S.

   Keys: S.T.A.R.S., Special Tactics and Rescue Service

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   The Special Tactics and Rescue Service is an American elite special forces division under the jurisdiction of the Raccoon Police Department, though privately funded and able to operate independently. It employed ex-military personnel and academic experts for appropriate positions within the police department. The overall idea was to form a team combining tactically-sound soldiers with scientists, allowing the team to operate in both anti-terrorism and increasingly-potent urban crime scenarios, as well as dealing with other emergencies.

8. #8Prototype Virus

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   The Prototype strain was developed for use in "Project W," advanced by Umbrella founder Oswell E. Spencer as part of a special screening process for identifying the most genetically gifted of the Wesker children. Only two of the thirteen remaining test subjects survived: Albert Wesker and Alex Wesker. They survived largely due to special genetic markers.

   Albert had injected the virus on July 24, 1998, during the Mansion Incident. William Birkin had given him the virus. This allowed him to survive impalement from the T-002 and to escape the Spencer Mansion before the Triggering System had detonated, unbeknownst to Umbrella and the remaining S.T.A.R.S. members. The power gained from the virus allowed Albert to become a global threat.

   Alex had injected the virus sometime after contracting an illness. She had survived the infection but lacked certain unique physical benefits that Albert had possessed. Alex had attempted to commit suicide in 2011 during the Sejm Island incident, but had only entered a dormant state due to the virus and awoke in a body mutated by her own T-Phobos Virus.

9. #9Tyrant Virus

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   Tyrant Virus, also known as the T-Virus, is the general name given to a series of mutant Progenitor virus strains.

   Initially developed by Umbrella Pharmaceuticals in the late 1960s, the primary goal of the "t-Virus Project" was to effectively eliminate the need for a large-scale conventional army and generate revenue for their eugenics program, the Wesker Project. This required two things: the virus had to be highly contagious to the point of infecting an entire target population and guarantee a 100% mortality rate.[1][2] However, such a virus was deemed impossible due to the tendency of highly contagious diseases to kill too many people at once and prevent further spread.

   By 1978, the development focus shifted from creating a lethal, highly contagious virus to one that would mutate hosts to become physically stronger and remain alive despite organ failures and severe brain damage. The latter led to murderous aggression and an obsessive hunger that drove individuals to cannibalism. Additionally, with the discovery in 1981 that approximately 10% of any population was naturally immune or unmutated asymptomatic carriers, Phase 2 of the research project aimed at finding workarounds. While an improved t-Virus with 0% immunity was being developed, the Arklay Laboratory team, led by Dr. William Birkin, engineered a new species of animal that could hunt down and kill survivors. This effort began with the creation of simple Bio-Organic Weapons such as the Web Spinner and progressed with the development of the genetically chimeric Hunter α.

10. #10William Birkin

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    Dr. William Birkin is a virologist who worked for Umbrella Pharmaceuticals in the 1970s-1990s. One of the leading scientists behind the t-Virus and discoverer of the Golgotha Virus of which he was head of the research project. He is the husband of Annette Birkin and father of Sherry Birkin.

11. #11Arklay Laboratory

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    The Arklay Laboratory is a research outpost located deep within the Arklay Mountains in the Midwestern United States. As with all other facilities in the United States, the Arklay Laboratory was managed by Umbrella USA. This facility was one of the first built by Umbrella and pioneered bioweapons research.

12. #12Umbrella Pharmaceuticals

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    Umbrella Pharmaceuticals is a European company responsible for the production of pharmaceuticals. Founded in the late 1960s, it became a subsidiary of Umbrella, a conglomerate spanning various industries from medicines to luxury travels. Until then, it is a leading member of the Federation of Pharmaceutical Companies.

13. #13Bioterrorism Security Assessment Alliance, B.S.A.A.

    Keys: Bioterrorism Security Assessment Alliance, BSAA

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    The Bioterrorism Security Assessment Alliance (BSAA) is an international counter-terrorism organisation sanctioned by the United Nations. It was formed during the War on Terror as a means of more readily combating the rising use of biological weaponry since the collapse of Umbrella Pharmaceuticals. Originally founded by the Federation of Pharmaceutical Companies as a private paramilitary agency, the UN allowed its continued private funding as late as 2009, understanding that footing the bill on terrorism-affected countries was counterproductive.

14. #14Raccoon City

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    Raccoon City was a small, industrialized city located in Arklay County, an isolated mountain county in the Midwestern United States. It was destroyed during the T-Virus outbreak in 1998. At present, the area is cordoned off to the rest of the world by a U.S. government facility.

15. #15Cerberus, MA-39

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    The Cerberus was an early attempt at creating a controllable Bio Organic Weapon by Umbrella USA, in a project led by the Arklay Laboratory.

    The Cerberus Project began in the early 1980s as the β strain was developed. It was hoped that the improved t-Virus strain would create mutants more adequate for sale as military products, and dobermans were specifically selected for the project due to their traits favouring military service. Though they suffered skin deterioration, their muscles were left largely intact, and this and their increased strength and aggression made them more dangerous. As this B.O.W. species was created from an existing animal, unlike the Hunter Program, the cost to create the Cerberus prototypes was low. Deemed a success, the later Cerberuses were created by cloning one of the prototypes. The Arklay Laboratory conducted testing on these dogs in the courtyard until the t-Virus outbreak in 1998 when they escaped. Hungry and lacking their Umbrella trainers, they turned feral and began killing and eating hikers out in the Arklay Mountains.

    When exposed to the β strain, one of the Doberman test subjects experienced a dramatic increase in strength and fighting instincts. The subject also lost the ability to be afraid, making it unperturbed by loud noises such as gunshots. In keeping with a dog's inherently sociable nature, the test subject was able to be trained to follow basic orders. This test subject was subsequently cloned to ensure all Cerberuses had the same advantages.

16. #16Tyrant Virus

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    Tyrant Virus, also known as the t-Virus, is the general name given to a series of mutant Progenitor virus strains.

    Initially developed by Umbrella Pharmaceuticals in the late 1960s, the primary goal of the "t-Virus Project" was to effectively eliminate the need for a large-scale conventional army and generate revenue for their eugenics program, the Wesker Project. This required two things: the virus had to be highly contagious to the point of infecting an entire target population and guarantee a 100% mortality rate. However, such a virus was deemed impossible due to the tendency of highly contagious diseases to kill too many people at once and prevent further spread.

    Like any other virus, t-Viruses make contact with a cell's membrane and insert their genetic coding into the cell. The viral genome is absorbed into the cell, hijacking its intended functions and using them to produce virions similar to the original virus. The newly formed virions are then released from the host cell and infect neighboring cells, initiating the process once again.

    Several diseases have been associated with t-Virus infection. The first, tentatively referred to as "Progenitor disease," is a fatal viral illness caused by Progenitor and early t-Virus strains. The exact mechanism of this disease is unknown, including whether it triggers a cytokine storm or rapidly mutates the patient until death. However, the most common disease caused by t-Viruses is Cannibal Disease, a condition in which patients mutate to gain enhanced survival capabilities at the cost of brain damage and homicidal urges. Advanced-stage Cannibal Disease patients are referred to as "Zombies," while pre-symptomatic and early-symptomatic cases can be treated with antiretroviral drugs.

17. #17Hunter

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    "Hunters" are a group of human-animal hybrids which were genetically engineered as biological weapons. Hunter species were created through the grafting of reptilian donor DNA to a fertilized human embryo with the aid of the t-Virus as a bonding agent, with the exception of the Hunter γ, which reversed the process with human DNA grafted into the genome of fertilized amphibian spawn. The Hunters were one of Umbrella's more successful products and among their oldest, having entered production with the Hunter α in the 1980s. Following Umbrella's demise, other bio-weapon manufacturers used the research data to create new Hunter species, with the Farfarello being among the latest iterations.

18. #18Excella Gionne

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    Excella Gionne is a British-Italian businesswoman. She is known for her leadership of Tricell, Inc., Africa and her involvement in Tricell's bio-weapons program. Excella Gionne was born into the Gionnes, a dynasty of wealthy Italian merchants. Through a grandmother, she was also closely related to the British Travis family, who had founded Tricell in the years before her birth. Academically impressive, Gionne was elevated to university education at a young age, and graduated with a BSc majoring in genetic engineering.

19. #19Golgotha Virus

    Keys: Golgotha Virus, G-virus

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    The Golgotha Virus, abbreviated as G-Virus, is a retrovirus in the Progenitor family of viruses. Golgotha was developed by william birkin of Umbrella USA as a bioweapon to rival and surpass the Tyrant Virus. The two viruses, while being descended from Progenitor, are totally dissimilar. Whereas the t-Virus typically causes relatively minor mutations in human hosts, such as Zombies and Tyrants, Golgotha causes such extreme genetic mutations that victims are no longer recognizable as human. Human t-Virus mutants are almost unanimously infertile, while Golgotha's "G" mutants are highly fertile and capable of asexual reproduction. The t-Virus causes necrosis of the body as a side-effect, while Golgotha is capable of repairing dead cells and even reviving the dead. Because of these factors, Golgotha is regarded as one of the greatest threats to the planet if an outbreak were to occur.

    Golgotha has extreme effects on the human body. The virus infects cells close by, turning them into so-called "G-Cells." These G-Cells then produce more of the virus, which spreads further across the body. As this gradual spread starts from the point of infection, the body may mutate asymmetrically.

    Golgotha's extreme mutations are not stopped simply from the creation of G-Cells. If part of the body is injured, it will regenerate, ultimately causing the host's DNA to be rewritten, leading to significant changes in the body during the regeneration. In the case of Dr. Birkin, he grew an entirely new, functional head, with his original head being moved down to the chest and eventually disappearing entirely.[14] Other noticeable aspects of the extreme mutations were the growth of a second pair of arms, which later mutated further into feet, and the reshaping of the rib cage into a mouth with bone teeth. With each physical trauma he received, Birkin's mutations grew more and more severe, until his form could no longer be recognized as human.

20. #20Tyrant

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    A Tyrant is a human bio-weapon created through either a primary t-Virus infection to create a weapon, or the cloning of such specimens, with the intent to be used as super soldiers on the battlefield. Umbrella USA pioneered research on human mutants from 1988 to 1998 in their Tyrant Project, named after the virus itself. Tyrants are distinguished from the typical human mutant, Zombies, by possessing certain genes relating to intelligence. Tyrants were intended to be the "ultimate bio-weapon" for military use due to this intelligence. Ultimately, specimens and research outlived Umbrella itself.

    The Tyrant Project's experiment outlines ultimately produced two main varieties of Tyrant to serve as B.O.W. products – the 'infiltration type' and 'combat type', respectively. The role of the infiltration-type is to blend in with a population centre to take part in covert operations, and are typically given heavy clothing to aide this; they are generally the more human in appearance. Combat types meanwhile are intended for battle, and are typically taller and deformed, and are often naked.

    As a typical effect of t-Virus infection, Tyrants experience increased production of Human Growth Hormone, though this hormone is produced at greater quantities than that of Zombies. While the shortest of Tyrants, the T-103 series, were close to 7 feet in height, a later Tyrant series produced by a third party was pushing 12 feet in height.

    Tyrants are also noted for their impressive physical abilities, being capable of jumping several storeys, bursting through concrete, flipping over tanks, and even redirecting rockets. Combat-type Tyrants experience extended arm growth resulting in a claw on at least one arm – muscle strength in the Tyrants is powerful enough human beings can be impaled and held up by these claws. Being developed for covert ops, infiltration types like the T-103 do not have claws unless the power limiter has been disabled.

21. #21Uroboros Virus

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    Uroboros is an RNA virus in the Progenitor family. It was engineered in the 21st century by Dr. Albert Wesker as the ultimate eugenics tool. Currently, there is no known vaccine for either strain of Uroboros. The virus is named after the Ouroboros in Greek mythology, which is a snake or snake-like creature that consumed itself.

    Comparable to the Progenitor virus, the Uroboros disease is noted to be almost always lethal in humans, with the exception of those with a particular genetic trait shared with the Ndipaya King. The disease goes through two stages, which can be defined as early and later symptomatic stages.

    In the early symptomatic stage, patients are known to experience sweating, labored breathing, and confusion or delirium. The Uroboros Project research team noted in their findings that the onset of symptoms appeared immediately after infection. However, it should be noted that patients in the lab trial were each infected with massive viral loads, equating to one vial for people over 60 kg and two-thirds for those at 40–60 kg.

    In the later stage of infection, the patient's condition will develop in one of two ways. If the patient has the advantageous genetic trait, the virus will enter a lysogenic stage and mutate the host at a slow rate. Patients without this trait, however, will experience runaway mutations that result in the patient being violently torn apart and killed. The infected biomatter continues to endure as its own separate entity, known only as "Uroboros".

    Like the Progenitor and Golgotha viruses, Uroboros is able to repair dead cells and revive the dead, which results in Zombies who demonstrate neither superhuman abilities nor become typical Uroboros. The extent of Tricell's research into Uroboros Zombies is limited, however, and should be noted.

    From a biological standpoint, Uroboros creatures can be described as anomalous masses of black biomatter. This mass often has tubular characteristics, echoing its namesake, though rather than resembling a snake, these creatures' tubules branch off from one another like tree roots, and can be melded back into the mass to grow elsewhere. When an Uroboros creature makes contact with other organisms, it consumes and converts them into biomatter for its own growth.

22. #22Tricell

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    Tricell is a multi-industrial conglomerate, prominent in the Federation of Pharmaceutical Companies. It was a conglomerate of three organizations descended from Travis Enterprises. Its name was derived from the triumvirate of "cells" that formed it.

    The three portions that make up Tricell up are the Pharmauceutical, Natural Resources and Shipping sectors.

    The company was one of the more prominent members of the Federation of Pharmaceutical Companies along with companies such as the Umbrella Corporation. Eventually, Umbrella would prove to be too troublesome to the Federation, heavily involved in the business of Bio Organic Weapons. This practice would eventually prove to be the undoing of the company.

    Wesker agreed to provide Tricell with the viral samples of the Tyrant virus and the T-Veronica virus for research in exchange for capital to add to his accumulated resources which are salvaged from Umbrella which he initially intended to replace.

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