Scream

Donna became a security guard for the Life Foundation. As part of their program to create a super-powered security force, the Life Foundation scientist merged the resulting creatures with five of their most skilled and trusted employees. One of those employees was Donna. She fled back to the Life Foundation's base in the Mojave Desert. Spider-Man stowed away on her hovercraft and released Brock. Diego and the other new symbiotes lost the resulting battle, and they apparently died from accelerated aging when Brock used a metabolic accelerator on them. Her symbiote was turned into dust and her body caught in a massive explosion.

It was later revealed that Donna left with their immature symbiotes and hoped that Brock would work with them so as to teach them control. Brock refused and Diego had a psychotic episode and went wild in Times Square. She succeeded in drawing the attention of Brock and Reilly. Brock fought with Diego, and only the intervention of Reilly saved her.

The other "guardian" symbiotes took him to Chicago. He managed to escape. Brock reunited with Venom before Diego could kill him as well and defeated her. Diego somehow gained a measure of control over her symbiote, or at least reached a modus vivendi with it. To make up for her past behavior, she began seeking out other symbiotes and helping their human hosts to cope. She soon learned of an alien called Xenophage that preyed on symbiotes. With Brock's help she defeated it.

In Diego's most recent appearance, she found the Xenophage's ship. Along with Brock and Wolverine, she traveled to an alien dimension and returned safely to Earth.

Donna Diego met her demise and scream died with her

Years later, seemingly forgotten, Scream would be resurrected by her older sibling Carnage, now under the thrall of Knull, the Symbiote God, and used her as a general and leader in his Symbiote armies, intending to hunt down the Codexes of other Symbiote hosts and devour their spines to awaken Knull. Scream would bond with former Venom/Mania host, Patricia Robertson, and drawn by both Patricia's memories, and Carnage's orders, would seek out second Mania host, Andrea Benton. Taking on Donna's personality, Scream was overwhelmed by voices, and fell to Knull, attacking Andi before Patricia got her under control. Carnage would arrive in person, and cause Scream to once more fall under control

But when she was defeated again a scintest locked her up and took her to a life foundation lab

Its skin is yellow and red eyes white hair white and red her skin can change into a multitude of weapons. As Scream, the Symbiote can grant its host an elongated jaw, fangs, claws, and prehensile hair which are really part of its body. Genetic memory, gains new knowledge from previous hosts.

the most effective method to take down the symbiote is the use of extreme sound / sonic.Feb or fire