Reine Murasame

Reine is unarguably a beautiful woman with pale skin. She still looks to be in her 20s, despite saying that she hasn't slept in 30 years. She has long, unkempt, pale blue hair which is tied into a right-side ponytail and blue eyes which seem to always be sleepy. Her most distinct feature is the pair of dark circles beneath her eyes. She wears a pair of glasses with a circular frame. Her height is 164 cm, and her three sizes are B95/W63/H89.

She is usually or always seen with a small blue teddy bear that fits in her breast pocket. During her duty on Fraxinus, she wears 's uniform, while as a Physics teacher at Shido's school, she wears a long white lab coat over a pink shirt with a rather low V-neck collar, a purple miniskirt, a pair of black stockings, and a pair of blue teddy bear slippers. She also wears a small silver ring on her silver chain necklace.

When disguised as , Reine typically surrounds herself with some sort of mosaic that, while people can see and hear her, makes it impossible for people to determine her appearance or the sound of her voice. When talking with Shido after he traveled back in time, she temporarily took on the form of Rinne Sonogami, something which she described as using "another shape".

Reine is a very logical, reasonable, and mature woman. Surprisingly enough, and despite her usual cold demeanor, she has proven countless times to be a very sensitive, considerate and understanding person. She is quick-witted enough to adapt to the sudden appearance of the Yamai sisters and seamlessly integrate them into her class field trip without raising suspicions from others. She's also good at giving advice and coaching Shido during his dates with the Spirits, even Kotori seems to take her advice well.

Reine is very good with handling children as when Natsumi turned everyone but Shido into children she was able to calm them all instantly. She has also displayed this skill towards Shido himself, calming him down after he recognized Kotori as a Spirit. Shido himself stated that she is like a mother, which she seems to react to in a strange way.

She has a tendency to faint suddenly due to her suffering from sleep deprivation. Despite using extensive sleep medication, Reine is extremely insomniac, with herself remarking that she hasn't slept in 30 years. The cause for this is revealed to be caused by PTSD, with her suffering from repeated nightmares of Shinji's death every time she tries to go to sleep.